52 research outputs found
Walking-by-Logic: Signal Temporal Logic-Guided Model Predictive Control for Bipedal Locomotion Resilient to External Perturbations
This study proposes a novel planning framework based on a model predictive
control formulation that incorporates signal temporal logic (STL)
specifications for task completion guarantees and robustness quantification.
This marks the first-ever study to apply STL-guided trajectory optimization for
bipedal locomotion push recovery, where the robot experiences unexpected
disturbances. Existing recovery strategies often struggle with complex task
logic reasoning and locomotion robustness evaluation, making them susceptible
to failures caused by inappropriate recovery strategies or insufficient
robustness. To address this issue, the STL-guided framework generates optimal
and safe recovery trajectories that simultaneously satisfy the task
specification and maximize the locomotion robustness. Our framework outperforms
a state-of-the-art locomotion controller in a high-fidelity dynamic simulation,
especially in scenarios involving crossed-leg maneuvers. Furthermore, it
demonstrates versatility in tasks such as locomotion on stepping stones, where
the robot must select from a set of disjointed footholds to maneuver
successfully
Infer and Adapt: Bipedal Locomotion Reward Learning from Demonstrations via Inverse Reinforcement Learning
Enabling bipedal walking robots to learn how to maneuver over highly uneven,
dynamically changing terrains is challenging due to the complexity of robot
dynamics and interacted environments. Recent advancements in learning from
demonstrations have shown promising results for robot learning in complex
environments. While imitation learning of expert policies has been
well-explored, the study of learning expert reward functions is largely
under-explored in legged locomotion. This paper brings state-of-the-art Inverse
Reinforcement Learning (IRL) techniques to solving bipedal locomotion problems
over complex terrains. We propose algorithms for learning expert reward
functions, and we subsequently analyze the learned functions. Through nonlinear
function approximation, we uncover meaningful insights into the expert's
locomotion strategies. Furthermore, we empirically demonstrate that training a
bipedal locomotion policy with the inferred reward functions enhances its
walking performance on unseen terrains, highlighting the adaptability offered
by reward learning
HLungDB: an integrated database of human lung cancer research
The human lung cancer database (HLungDB) is a database with the integration of the lung cancer-related genes, proteins and miRNAs together with the corresponding clinical information. The main purpose of this platform is to establish a network of lung cancer-related molecules and to facilitate the mechanistic study of lung carcinogenesis. The entries describing the relationships between molecules and human lung cancer in the current release were extracted manually from literatures. Currently, we have collected 2585 genes and 212 miRNA with the experimental evidences involved in the different stages of lung carcinogenesis through text mining. Furthermore, we have incorporated the results from analysis of transcription factor-binding motifs, the promoters and the SNP sites for each gene. Since epigenetic alterations also play an important role in lung carcinogenesis, genes with epigenetic regulation were also included. We hope HLungDB will enrich our knowledge about lung cancer biology and eventually lead to the development of novel therapeutic strategies. HLungDB can be freely accessed at http://www.megabionet.org/bio/hlung
Real-time Monitoring for the Next Core-Collapse Supernova in JUNO
Core-collapse supernova (CCSN) is one of the most energetic astrophysical
events in the Universe. The early and prompt detection of neutrinos before
(pre-SN) and during the SN burst is a unique opportunity to realize the
multi-messenger observation of the CCSN events. In this work, we describe the
monitoring concept and present the sensitivity of the system to the pre-SN and
SN neutrinos at the Jiangmen Underground Neutrino Observatory (JUNO), which is
a 20 kton liquid scintillator detector under construction in South China. The
real-time monitoring system is designed with both the prompt monitors on the
electronic board and online monitors at the data acquisition stage, in order to
ensure both the alert speed and alert coverage of progenitor stars. By assuming
a false alert rate of 1 per year, this monitoring system can be sensitive to
the pre-SN neutrinos up to the distance of about 1.6 (0.9) kpc and SN neutrinos
up to about 370 (360) kpc for a progenitor mass of 30 for the case
of normal (inverted) mass ordering. The pointing ability of the CCSN is
evaluated by using the accumulated event anisotropy of the inverse beta decay
interactions from pre-SN or SN neutrinos, which, along with the early alert,
can play important roles for the followup multi-messenger observations of the
next Galactic or nearby extragalactic CCSN.Comment: 24 pages, 9 figure
Dendritic cell type 3 arises from Ly6C monocyte-dendritic cell progenitors
Conventional dendritic cells (cDCs) are professional antigen-presenting cells that control the adaptive immune response. Their subsets and developmental origins have been intensively investigated but are still not fully understood as their phenotypes, especially in the DC2 lineage and the recently described human DC3s, overlap with monocytes. Here, using LEGENDScreen to profile DC vs. monocyte lineages, we found sustained expression of FLT3 and CD45RB through the whole DC lineage, allowing DCs and their precursors to be distinguished from monocytes. Using fate mapping models, single-cell RNA sequencing and adoptive transfer, we identified a lineage of murine CD16/32CD172a DC3, distinct from DC2, arising from Ly6C monocyte-DC progenitors (MDPs) through Lyz2Ly6CCD11c pro-DC3s, whereas DC2s develop from common DC progenitors (CDPs) through CD7Ly6CCD11c pre-DC2s. Corresponding DC subsets, developmental stages, and lineages exist in humans. These findings reveal DC3 as a DC lineage phenotypically related to but developmentally different from monocytes and DC2s
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